The role of adenosine on motor control

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The role of adenosine on motor control

Abstract Caffeine is a competitive antagonist at adenosine receptors. Receptor up-regulation during chronic drug treatment has been proposed to be the mechanism of tolerance to the behavioral stimulant effects of caffeine.

This study reassessed the role of adenosine receptors in caffeine tolerance. Separate groups of rats were given scheduled access to drinking bottles containing plain tap water or a 0.

Adenosine triphosphate - Wikipedia

Apparent pA2 values for tolerant and control rats also were comparable: Thus, the adenosine-antagonist activity of caffeine was undiminished in tolerant rats. The effects of chronic caffeine administration on parameters of adenosine receptor binding and function were measured in cerebral cortex.

There were no differences between brain tissue from control and caffeine-treated rats in number and affinity of adenosine binding sites or in receptor-mediated increases A2 adenosine receptor and decreases A1 adenosine receptor in cAMP accumulation.

The role of adenosine on motor control

These results are consistent with theoretical arguments that changes in receptor density should not affect the potency of a competitive antagonist. Experimental evidence and theoretical considerations indicate that up-regulation of adenosine receptors is not the mechanism of tolerance to caffeine-induced stimulation of locomotor activity.Each individual muscle fiber is innervated by a single branch from a motor neuron.

This branch (telodendron) forms a neuromuscular junction (NMJ) with the muscle cell membrane (sarcolemma), Impulses arriving on the nerve fiber are transmitted to the sarcolemma and ultimately cause the contraction of the muscle fiber.

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2, functions. To prevent adenosine accumulation in the extra-cellular fluid and control adenosine’s effects on other cells, adenosine is taken back up into the cells by the nucleoside.

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The role of adenosine on motor control

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